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Evaluation pre- and post surgery dynamics of cognitive development in pediatric epilepsy surgery patients, design pre- andpost surgery protocol for neuropsychological assessment
Maulisová, Alice ; Niederlová, Markéta (advisor) ; Krámská, Lenka (referee) ; Kulišťák, Petr (referee)
Epilepsy represents the most common neurological disease, its prevalence reaching up to 1%, and around 30% of patients become refractory to treatment. In these patients, epilepsy surgery is often their only chance for disease-free life. Aetiology of epilepsy is heterogenous; we recognize genetic, structural- metabolic epilepsy and epilepsy with unknown aetiology. Patients with focal pharmacoresistant epilepsy may become candidates for epilepsy surgery; the same does not apply to patients with metabolic or neurodegenerative disease. Multiple factors influence decision about epilepsy surgery, the most important ones being (i) the type of known or presumed structural lesion and (ii) the possibility to precisely delineate the epileptogenic zone (the area of seizure generation). Another factor that needs to be accounted for is the proximity of epileptogenic zone to the eloquent cortical areas (the areas with important neurological functions, e.g. motor or speech functions). Epilepsy surgery principally aims for complete removal the epileptogenic zone, and subsequently for complete freedom from seizures. Hypothesis on the localization of the epileptogenic zone arises from the combined information gained from various diagnostic, mostly neuroimaging, methods. Cognitive profile examination includes...
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